Tau蛋白：阿尔茨海默病的关键生物标志物

Tau蛋白对维持神经细胞内的微管结构的稳定发挥了重要作用。在阿尔茨海默病（AD）中，Tau蛋白的异常过度磷酸化会显著促进神经退行性过程。研究发现，相比于β淀粉样蛋白斑块，磷酸化Tau蛋白更适合作为AD疾病进展和神经纤维病理学的指标。

高度磷酸化的Tau蛋白（p-tau）组成的神经纤维缠结是AD的标志性病理之一。但是Tau蛋白发挥稳定微管的作用，是神经元发挥功能必不可少的。只有当Tau蛋白发送异常磷酸化，不断聚集并形成纤维缠结时，才会成为生成AD的“凶手”。近期的研究还发现，Tau蛋白是阻止AD发生的关键成分，可有效帮助神经胶质细胞清除毒性的脂质，减少对神经元的损伤。

SignalChem Biotech（义翘神州全资子公司）提供包括Tau-441及其突变体在内的多种优质重组Tau蛋白和磷酸化Tau蛋白，全力支持Tau蛋白在神经退行性疾病中的研究。

 

 

SignalChem Biotech Tau蛋白

Tau-411, GSK3beta-phosphorylated (Cat#: T08-50FN)	Tau-411, Biotinylated (Cat#: T08-54B2N)	Tau-411, DYRK1A-phosphorylated (Cat#: T08-50RN)
The purity of Tau441, GSK3β-phosphorylated was determined to be >90% by densitometry, approx. MW 64-68 kDa.	The purity of biotinylated Tau-441 was determined to be >90% by densitometry. Observed MW ~64 kDa. Calculated MW 45.9 kDa.	The purity of Tau-441, DYRK1A-phosphorylated was determined to be >90% by densitometry, approx. MW 68-71 kDa.

SignalChem Biotech全系列Tau蛋白

货号	名称	货号	名称
T08-50BN	Tau-441, BRSK2-phosphorylated	T08-55HN	Tau-441 (231-421) Protein
T08-50CN	Tau-441, CAMK2-phosphorylated	T08-55IN	Tau-441 (231-391) Protein
T08-50FN	Tau-441, GSK3beta-phosphorylated	T08-55JN	Tau-441 (99-441) Protein
T08-50KN	Tau-441, PHKG2-phosphorylated	T08-55KN	Tau-441 (127-421) Protein
T08-50LN	Tau-441, PKA-phosphorylated	T08-55LCB	Tau-441 (216-391), Biotinylated
T08-50N	Tau-441, BRSK1-phosphorylated	T08-55LN	Tau-441 (216-391) Protein
T08-50ON	Tau-441, TTBK1-phosphorylated	T08-55LNB	Tau-441 (216-391), Biotinylated
T08-50RN	Tau-441, DYRK1A-phosphorylated	T08-55MN	Tau-441 (50-441) Protein
T08-50RNB	Tau-441, DYRK1A-phosphorylated & Biotinylated	T08-55N	Tau-441 (244-372) Protein
T08-52BN	Tau-441 (dN296) Protein	T08-55NB	Tau-441 (244-372), Biotinylated
T08-53BN	Tau-441 (S198A) Protein	T08-55ON	Tau-441 (50-391) Protein
T08-52N	Tau-441 (dK280) Protein	T08-55NN	Tau-441 (50-421) Protein
T08-53DN	Tau-441 (S214A) Protein	T08-56DN	Tau-441 (G272V) Protein
T08-53CN	Tau-441 (S199E) Protein	T08-56CN	Tau-441 (L266V) Protein
T08-53GN	Tau-441 (S404E) Protein	T08-56EN	Tau-441 (N279K) Protein
T08-53HN	Tau-441 (S404A) Protein	T08-56FBN	Tau-441 (P301L), Biotinylated
T08-53N	Tau-441 (S198E) Protein	T08-56FN	Tau-441 (P301L) Protein
T08-54B2N	Tau-441, Biotinylated	T08-56GN	Tau-441 (P301S) Protein
T08-54BN	Tau-441, Biotinylated	T08-56HN	Tau-441 (S305N) Protein
T08-54H	Tau-441 Protein	T08-56JN	Tau-441 (V337M) Protein
T08-54N	Tau-441 Protein	T08-56KN	Tau-441 (S352L) Protein
T08-55BN	Tau-441 (1-421) Protein	T08-56MN	Tau-441 (R406W) Protein
T08-55CN	Tau-441 (1-391) Protein	T08-56N	Tau-441 (K257T) Protein
T08-55DN	Tau-441 (151-441) Protein	T08-56ON	Tau-441 (T217A) Protein
T08-55EN	Tau-441 (151-421) Protein	T08-56VN	Tau-441 (A152T) Protein
T08-55FN	Tau-441 (151-391) Protein	T08-57GN	Tau-441 (P301S) Protein Monomer
T08-55GN	Tau-441 (231-441) Protein	T08-58GN	Tau-441 (P301S) Pre-Formed Fibril
T08-55H	Tau-441 (244-372) Protein	30132-H07E	Human Tau / TAU441 Protein (isoform 2N4R, His Tag)