170 种+：超全的新冠病毒突变蛋白试剂库_公司新闻

品牌商

北京义翘神州科技股份有限公司(Sino Biological Inc.)

入驻年限：15 年

联系人：
客服部
所在地区：
北京
业务范围：
技术服务、试剂、抗体、细胞库 / 细胞培养、ELISA 试剂盒
经营模式：
生产厂商

170 种+：超全的新冠病毒突变蛋白试剂库

人阅读发布时间：2021-06-25 14:28

在目前已经检测分离到的新冠突变株中，发生在 Spike 蛋白受体结合域的多个突变是主要的突变类型，也是最令人担心的突变。Spike 蛋白受体结合域是新冠病毒结合宿主受体的主要结构，该结构的突变则有可能导致增强与受体的亲和力、减弱中和抗体效应或者造成病毒的免疫逃逸。

新冠突变株中同时存在 N 蛋白突变。N 蛋白具有高度保守型，常被用作新冠抗原快速检测的标志物。目前已经上市的新冠抗原检测试剂是否可以检测到突变后的N蛋白以及检测灵敏度和特异性是否会受到突变的影响需要进一步的研究。

义翘神州开发了近 170 种新冠突变体蛋白，可用于抗体、疫苗等效力研究。

新冠突变体蛋白试剂库

Kappa | B.1.617.1；Delta | B.1.617.2；B.1.617.3

毒株	货号	抗原	突变位点	标签
B.1.617	40588-V07E16	N	D377Y	His
B.1.617	40588-V07E20	N	R203M, D377Y	His
B.1.617.2	40588-V07E29	N	D63G, R203M, D377Y	His
B.1.617.3	40588-V07E30	N	P67S, R203M, D377Y	His
B.1.617	40591-V08H19	S1	D614G, E154K, E484Q, L452R, P681R	His
B.1.617	40589-V08B12	S1+S2 ECD	D614G, E154K, E484Q, E1072K, K1073R, L452R, P681R	His
B.1.617	40592-V08H28	RBD	L452R	His
B.1.617	40592-V08H81	RBD	E484Q	His
B.1.617/B.1.617.1/b.1.617.3	40592-V08H88	RBD	L452R，E484Q	His
B.1.617/B.1.617.1/b.1.617.3	40592-V02H2	RBD	L452R，E484Q	Fc
B.1.617.2	40592-V08H90	RBD	L452R, T478K	His
B.1.617.2	40592-V08H91	RBD	T478K	His

Epsilon | B.1.427/B.1.429 (U.S.A*)

毒株	货号	抗原	突变位点	标签
B.1.429/B.1.427	40591-V08H17	S1	W152C, L452R, D614G	His
B.1.429/B.1.427	40588-V07E9	N	T205I	His

Alpha | B.1.1.7 (U.K.*)

毒株	货号	抗原	突变位点	标签
B.1.1.7	40588-V07E1	N	R203K, G204R	His
B.1.1.7	40588-V07E17	N	E378Q	His
B.1.1.7	40588-V07E4	N	I292T	His
B.1.1.7	40588-V07E7	N	D3L, R203K, G204R, S235F	His
B.1.1.7	40588-V07E8	N	D3L, S235F	His
B.1.1.7	40589-V08B6	S1+S2 ECD	H69del, V70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H	His
B.1.1.7	40591-V08H12	S1	H69del, V70del, Y144del, N501Y, A570D, D614G, P681H	His
B.1.1.7	40591-V08H12-B	S1-Biotinylated	H69del, V70del, Y144del, N501Y, A570D, D614G, P681H	His
B.1.1.7	40591-V08H7	S1	HV69-70 deletion, N501Y, D614G	His
B.1.1.7	40592-V02H1	RBD	N501Y	Fc
B.1.1.7	40592-V08H18	RBD	S494P	His
B.1.1.7	40592-V08H82	RBD	N501Y	His
B.1.1.7	40592-V08H82-B	RBD-Biotinylated	N501Y	His
B.1.1.7, B.1.237	40588-V07E3	N	S194L	His
B.1.1.7, B.1.351, A.2.2	40588-V07E2	N	P13L	His

Beta | B.1.351 (South Africa*)

毒株	货号	抗原	突变位点	标签
B.1.351	40588-V07E9	N	T205I	His
B.1.351	40589-V08B11	S1+S2 ECD	D80A,L242del,A243del,L244del,R246I,E484K,K417N,N501Y,D614G,A701V	His
B.1.351	40589-V08B7	S1+S2 ECD	L18F, D80A, D215G, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G, A701V	His
B.1.351	40589-V08B7-B	S1+S2-Biotinylated	L18F, D80A, D215G, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G, A701V	His
B.1.351	40589-V08B9	S1+S2 ECD	D80A, K417N, E484K, N501Y, D614G, A701V	His
B.1.351	40591-V08H10	S1	K417N, E484K, N501Y, D614G	His
B.1.351	40591-V08H13	S1 NTD	L18F, D80A, D215G, LAL242-244 deletion, R246I	His
B.1.351	40591-V08H15	S1	L18F, D80A, D215G, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G	His
B.1.351	40592-V08H59	RBD	K417N	His
B.1.351	40592-V08H59-B	RBD-Biotinylated	K417N	His
B.1.351	40592-V08H84	RBD	E484K	His
B.1.351	40592-V08H84-B	RBD-Biotinylated	E484K	His
B.1.351	40592-V08H85	RBD	K417N, E484K, N501Y	His
B.1.351	40592-V08H85-B	RBD-Biotinylated	K417N, E484K, N501Y	His

Gamma | P.1 (Brazil*)

毒株	货号	抗原	突变位点	标签
P.1	40588-V07E11	N	P80R	His
P.1	40589-V08B8	S1+S2 ECD	L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I	His
P.1	40591-V08H14	S1	L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y	His
P.1	40591-V08H5	S1	T20N, D614G	His
P.1	40592-V08H86	RBD	K417T, E484K, N501Y	His

Mink Variant (Denmark*)

货号	抗原	突变位点	标签
40591-V08H8	S1	ΔH69/ΔV70, Y453F, D614G	His
40592-V08H80	RBD	Y453F	His

High Frequency Mutation of Nucleocapsid

货号	抗原	突变位点	标签
40588-V07E1	N	R203K, G204R	His
40588-V07E11	N	P80R	His
40588-V07E2	N	P13L	His
40588-V07E3	N	S194L	His
40588-V07E4	N	I292T	His
40588-V07E9	N	T205I	His

More Variants

货号	抗原	突变位点	标签
40589-V08B4	S1+S2 ECD	D614G	His
40589-V08B5	S1+S2 ECD	HV69-70 deletion, D614G, D796H	His
40590-V02H1	S2	E780Q	Fc
40591-V02H3	S1	D614G	Fc
40591-V08H11	S1	N234Q	His
40591-V08H16	S1	Q677H	His
40591-V08H3	S1	D614G	His
40591-V08H4	S1	A222V, D614G	His
40591-V08H6	S1	L18F, D614G	His
40591-V08H9	S1	HV69-70 deletion, N439K, D614G	His
40592-V05H1	RBD	V367F	mFc
40592-V08H1	RBD	V367F	His
40592-V08H10	RBD	R408I	His
40592-V08H11	RBD	V341I	His
40592-V08H12	RBD	Y508H	His
40592-V08H14	RBD	N439K	His
40592-V08H15	RBD	V503F	His
40592-V08H16	RBD	A522V	His
40592-V08H19	RBD	A372S	His
40592-V08H2	RBD	N354D	His
40592-V08H20	RBD	A520S	His
40592-V08H21	RBD	A522S	His
40592-V08H22	RBD	D405V, Q414A	His
40592-V08H23	RBD	Q414E	His
40592-V08H24	RBD	P384L	His
40592-V08H25	RBD	A348S	His
40592-V08H26	RBD	F338L	His
40592-V08H27	RBD	F377L	His
40592-V08H29	RBD	P521S	His
40592-V08H30	RBD	T478I	His
40592-V08H31	RBD	V483I	His
40592-V08H32	RBD	S359N	His
40592-V08H33	RBD	K378R	His
40592-V08H34	RBD	Q409E	His
40592-V08H35	RBD	I472V	His
40592-V08H36	RBD	A372T	His
40592-V08H37	RBD	A344S	His
40592-V08H39	RBD	A520V	His
40592-V08H4	RBD	A435S	His
40592-V08H40	RBD	E406Q	His
40592-V08H41	RBD	F490S	His
40592-V08H42	RBD	K378N	His
40592-V08H43	RBD	N370S	His
40592-V08H44	RBD	Q414R	His
40592-V08H45	RBD	S477I	His
40592-V08H46	RBD	S477N	His
40592-V08H47	RBD	T385A	His
40592-V08H48	RBD	T393P	His
40592-V08H49	RBD	V395I	His
40592-V08H5	RBD	V483A	His
40592-V08H50	RBD	A475V	His
40592-V08H51	RBD	G446V	His
40592-V08H52	RBD	G485S	His
40592-V08H53	RBD	G482S	His
40592-V08H54	RBD	K444R	His
40592-V08H55	RBD	N440K	His
40592-V08H56	RBD	E471Q	His
40592-V08H57	RBD	P479S	His
40592-V08H58	RBD	A352S	His
40592-V08H6	RBD	F342L	His
40592-V08H62	RBD	P337S	His
40592-V08H63	RBD	P521R	His
40592-V08H64	RBD	S477R	His
40592-V08H68	RBD	L455F	His
40592-V08H69	RBD	K458Q	His
40592-V08H7	RBD	K458R	His
40592-V08H70	RBD	N481D	His
40592-V08H71	RBD	F456L	His
40592-V08H72	RBD	Y505C	His
40592-V08H73	RBD	F456E	His
40592-V08H74	RBD	F486S	His
40592-V08H75	RBD	N487R	His
40592-V08H76	RBD	G446S	His
40592-V08H78	RBD	P499R	His