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北京义翘神州科技股份有限公司(Sino Biological Inc.)

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人骨成型蛋白-2(BMP-2)相关研究工具

1560 人阅读发布时间:2010-05-05 15:47

Bone Morphogenetic Protein 2

BMP-2 Alternative Names

BMP-2, BMP-2A

BMP-2 Protein & Antibody

Sino Biological offers a comprehensive set of research tools (33 products, including proteins, antibodies, ORF clones, etc.) for BMP related research. We offer BMP proteins and receptors from human and mouse. Our antibody products include mouse monoclonal and rabbit polyclonal antibodies for application such as ELISA, Western Blotting, IHC, etc. All of our antibodies were generated with recombinant full length protein as immunogen, which ensures better binding affinity and specificity to the native protein.

BMP-2 Protein, Recombinant

Molecule Species Description Cat No Size/Price
BMP-2 Human BMP-2 Protein, Recombinant 10426-HNAE Order
BMP-2 Human BMP-2/Fc Protein, Recombinant 10426-H01H 100µg($350); Order

  10426-HNAE: ED50 = 0.5-0.9 μg/ml. Measured by its ability to induce alkaline phosphatase production by MC3T3-E1 mouse osteoblastic cells.

BMP-2 Antibody

BMP-2 Related Areas

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>BMP Family>>BMP-2

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>BMP Family>>BMP-2

BMP-2 Related Products

Protein Products

Molecule Species Protein
BMP-5 Human BMP-5/Fc Protein, Recombinant
ALK-3/BMPRIA Human ALK-3/BMPRIA/Fc Protein, Recombinant
NBL1/DAND1 Human NBL1/DAND1 Protein, Recombinant
NBL1/DAND1 Human NBL1/DAND1/Fc Protein, Recombinant
Noggin Human Noggin/Fc Protein, Recombinant
Sclerostin/SOST Human Sclerostin/SOST Protein, Recombinant
GDF-15 Human GDF-15/Fc Protein, Recombinant

Antibody Products

Molecule Application Antibody
Human
NBL1/DAND1
WB, ELISA Rabbit Polyclonal Antibody
Human
NBL1/DAND1
WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human
Sclerostin/SOST
WB, ELISA Rabbit Monoclonal Antibody
Human
Sclerostin/SOST
ELISA Rabbit Polyclonal Anitbody
Human
Sclerostin/SOST
WB, ELISA Rabbit Polyclonal Antibody

cDNA Clone Products

Molecule Species cDNA Clone
BMP-2 Human Homo sapiens BMP-2 cDNA Clone(NM_001200.2)
BMP-3b/GDF-10 Human Homo sapiens BMP-3b/GDF-10 cDNA Clone(NM_004962.2)
BMP-4 Human Homo sapiens BMP-4 cDNA Clone(NM_001202.3)
BMP-5 Human Homo sapiens BMP-5 cDNA Clone(NM_021073.2)
BMP-7 Human Homo sapiens BMP-7 cDNA Clone(NM_001719.2)
BMP-9 Human Homo sapiens BMP-9 cDNA Clone(NM_016204.1)
ALK-3/BMPRIA Human Homo sapiens ALK-3/BMPRIA cDNA Clone(NM_004329.2)
ALK-6/BMPR-IB Human Homo sapiens ALK-6/BMPR-IB cDNA Clone(NM_001203.2)
BAMBI/NMA Human Homo sapiens BAMBI/NMA cDNA Clone(NM_012342.2)
Cerberus 1 Human Homo sapiens Cerberus 1 cDNA Clone(NM_005454.2)
COCO Human Homo sapiens COCO cDNA Clone(NM_152654.2)
NBL1/DAND1 Human Homo sapiens NBL1/DAND1 transcript variant 2 cDNA Clone(NM_005380.4)
Follistatin Human Homo sapiens Follistatin cDNA Clone(NM_013409.1)
Noggin Human Homo sapiens Noggin cDNA Clone(NM_005450.4)
TSK Human Homo sapiens tsukushin cDNA Clone(NM_015516.3)
GDF-3 Human Homo sapiens GDF-3 cDNA Clone(NM_020634.1)
GDF-9 Human Homo sapiens GDF-9 cDNA Clone(NM_005260.3)
GDF-15 Human Homo sapiens GDF-15 cDNA Clone(NM_004864.2)
RGM-C Human Homo sapiens RGM-C transcript variant a cDNA Clone(NM_213653.3)


BMP-2 Background

BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMPs that have been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2, BMP-4 and BMP-7 are known to be of major importance in bone formation and repair. In cancerous tissues BMP-2 protein may play an important role in the progression of glioma.

BMP-2 Related Studies

  1. Jiao X, et al. (2007) Heparan sulfate proteoglycans (HSPGs) modulate BMP-2 osteogenic bioactivity in C2C12 cells. J Biol Chem. 282(2):1080-6.
  2. Michon F, et al. (2008) BMP-2 and BMP-7 play antagonistic roles in feather induction. Development 135 (16):2797-805.

 

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